Skip navigation
Skip navigation

Hypotension is associated with diuretic resistance in severe chronic heart failure, independent of renal function

De Pasquale, Carmine G; Dunne, J S; Minson, R.B; Arnolda, Leonard

Description

Background: Diuretic resistance and systemic hypotension are common in chronic heart failure (CHF), however, the two have not been associated. Aims: Since blood pressure (BP) might be an important determinant of sodium excretion, we searched for an association between BP and diuretic dosage in severe CHF. Methods: Our heart failure database was retrospectively reviewed for patients with severe left ventricular systolic dysfunction. The 54-patient cohort was divided on the basis of frusemide...[Show more]

dc.contributor.authorDe Pasquale, Carmine G
dc.contributor.authorDunne, J S
dc.contributor.authorMinson, R.B
dc.contributor.authorArnolda, Leonard
dc.date.accessioned2015-12-07T22:53:45Z
dc.identifier.issn1388-9842
dc.identifier.urihttp://hdl.handle.net/1885/27863
dc.description.abstractBackground: Diuretic resistance and systemic hypotension are common in chronic heart failure (CHF), however, the two have not been associated. Aims: Since blood pressure (BP) might be an important determinant of sodium excretion, we searched for an association between BP and diuretic dosage in severe CHF. Methods: Our heart failure database was retrospectively reviewed for patients with severe left ventricular systolic dysfunction. The 54-patient cohort was divided on the basis of frusemide dosage (high-dose ≥250 mg daily, n=26). Results: Patients taking high-dose frusemide had higher serum creatinine, and lower systolic and diastolic BP. On logistic regression analysis, increased serum creatinine and reduced diastolic BP were independent predictors of the use of high-dose frusemide. Grouping these variables into tertiles, the odds ratio for the use of high-dose frusemide was 4.0 as diastolic BP decreased (p<0.01), and 6.8 as serum creatinine increased (p<0.001). Conclusions: We have found an association between hypotension and the use of high-dose frusemide in severe CHF, which is independent of renal function, and which may be an important physiologic mechanism of diuretic resistance in severe CHF. Crown
dc.publisherOxford University Press
dc.sourceEuropean Journal of Heart Failure
dc.subjectKeywords: creatinine; furosemide; loop diuretic agent; adult; aged; article; blood pressure monitoring; clinical article; controlled study; creatinine blood level; data base; diastolic blood pressure; disease severity; drug megadose; heart failure; heart left ventr Blood pressure; Diuretic resistance; Frusemide; Heart failure
dc.titleHypotension is associated with diuretic resistance in severe chronic heart failure, independent of renal function
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume7
dc.date.issued2005
local.identifier.absfor110299 - Cardiovascular Medicine and Haematology not elsewhere classified
local.identifier.ariespublicationu4201517xPUB54
local.type.statusPublished Version
local.contributor.affiliationDe Pasquale, Carmine G, Flinders Medical Centre
local.contributor.affiliationDunne, J S, Flinders Medical Centre
local.contributor.affiliationMinson, R.B, Flinders Medical Centre
local.contributor.affiliationArnolda, Leonard, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.startpage888
local.bibliographicCitation.lastpage891
local.identifier.doi10.1016/j.ejheart.2004.12.012
dc.date.updated2015-12-07T12:42:33Z
local.identifier.scopusID2-s2.0-23744514589
CollectionsANU Research Publications

Download

File Description SizeFormat Image
01_De Pasquale_Hypotension_is_associated_with_2005.pdf109.04 kBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator