Hypotension is associated with diuretic resistance in severe chronic heart failure, independent of renal function
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De Pasquale, Carmine G; Dunne, J S; Minson, R.B; Arnolda, Leonard
Description
Background: Diuretic resistance and systemic hypotension are common in chronic heart failure (CHF), however, the two have not been associated. Aims: Since blood pressure (BP) might be an important determinant of sodium excretion, we searched for an association between BP and diuretic dosage in severe CHF. Methods: Our heart failure database was retrospectively reviewed for patients with severe left ventricular systolic dysfunction. The 54-patient cohort was divided on the basis of frusemide...[Show more]
dc.contributor.author | De Pasquale, Carmine G | |
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dc.contributor.author | Dunne, J S | |
dc.contributor.author | Minson, R.B | |
dc.contributor.author | Arnolda, Leonard | |
dc.date.accessioned | 2015-12-07T22:53:45Z | |
dc.identifier.issn | 1388-9842 | |
dc.identifier.uri | http://hdl.handle.net/1885/27863 | |
dc.description.abstract | Background: Diuretic resistance and systemic hypotension are common in chronic heart failure (CHF), however, the two have not been associated. Aims: Since blood pressure (BP) might be an important determinant of sodium excretion, we searched for an association between BP and diuretic dosage in severe CHF. Methods: Our heart failure database was retrospectively reviewed for patients with severe left ventricular systolic dysfunction. The 54-patient cohort was divided on the basis of frusemide dosage (high-dose ≥250 mg daily, n=26). Results: Patients taking high-dose frusemide had higher serum creatinine, and lower systolic and diastolic BP. On logistic regression analysis, increased serum creatinine and reduced diastolic BP were independent predictors of the use of high-dose frusemide. Grouping these variables into tertiles, the odds ratio for the use of high-dose frusemide was 4.0 as diastolic BP decreased (p<0.01), and 6.8 as serum creatinine increased (p<0.001). Conclusions: We have found an association between hypotension and the use of high-dose frusemide in severe CHF, which is independent of renal function, and which may be an important physiologic mechanism of diuretic resistance in severe CHF. Crown | |
dc.publisher | Oxford University Press | |
dc.source | European Journal of Heart Failure | |
dc.subject | Keywords: creatinine; furosemide; loop diuretic agent; adult; aged; article; blood pressure monitoring; clinical article; controlled study; creatinine blood level; data base; diastolic blood pressure; disease severity; drug megadose; heart failure; heart left ventr Blood pressure; Diuretic resistance; Frusemide; Heart failure | |
dc.title | Hypotension is associated with diuretic resistance in severe chronic heart failure, independent of renal function | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.identifier.citationvolume | 7 | |
dc.date.issued | 2005 | |
local.identifier.absfor | 110299 - Cardiovascular Medicine and Haematology not elsewhere classified | |
local.identifier.ariespublication | u4201517xPUB54 | |
local.type.status | Published Version | |
local.contributor.affiliation | De Pasquale, Carmine G, Flinders Medical Centre | |
local.contributor.affiliation | Dunne, J S, Flinders Medical Centre | |
local.contributor.affiliation | Minson, R.B, Flinders Medical Centre | |
local.contributor.affiliation | Arnolda, Leonard, College of Medicine, Biology and Environment, ANU | |
local.description.embargo | 2037-12-31 | |
local.bibliographicCitation.startpage | 888 | |
local.bibliographicCitation.lastpage | 891 | |
local.identifier.doi | 10.1016/j.ejheart.2004.12.012 | |
dc.date.updated | 2015-12-07T12:42:33Z | |
local.identifier.scopusID | 2-s2.0-23744514589 | |
Collections | ANU Research Publications |
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