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Development of Plasmodium-specific liver-resident memory CD8(+) T cells after heat-killed sporozoite immunization in mice

Ghilas, Sonia; Enders, Matthias H; May, Rose; Holz, Lauren E; Fernandez-Ruiz, Daniel; Cozijnsen, Anton; Mollard, Vanessa; Cockburn, Ian; McFadden, Geoffrey I; Heath, William R; Beattie, Lynette


Malaria remains a major cause of mortality in the world and an efficient vaccine is the best chance of reducing the disease burden. Vaccination strategies for the liver stage of disease that utilise injection of live radiation-attenuated sporozoites (RAS) confer sterile immunity, which is mediated by CD8(+) memory T cells, with liver-resident memory T cells (T-RM) being particularly important. We have previously described a TCR transgenic mouse, termed PbT-I, where all CD8(+) T cells recognize...[Show more]

CollectionsANU Research Publications
Date published: 2021
Type: Journal article
Source: European Journal of Immunology
DOI: 10.1002/eji.202048757


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