Siggs, Owen; Miosge, Lisa; Yates (previously Loy), Adele; Kucharska, Edyta; Sheahan, Daniel; Brdicka, Tomas; Weiss, Arthur; Liston, Adrian; Goodnow, Christopher
Null mutations that cripple T cell receptor (TCR) signaling explain rare primary immunodeficiencies, but it is not understood why more common polymorphisms that lead to subtle TCR signaling defects are paradoxically associated with autoimmunity. Here we analyzed how a series of Zap70 variants with step-wise decreases in TCR signaling impacted upon opposing TCR functions of immunity and tolerance. One Zap70 variant, murdock, moderately decreased TCR signaling and thymic selection without...[Show more]
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.