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Coadministration with carbidopa enhances the antimyopic effects of levodopa in chickens

Thomson, Kate; Morgan, Ian; Kelly, Tamsin; Karouta, Cindy; Ashby, Regan


PURPOSE. Topical application of levodopa inhibits the development of form-deprivation myopia (FDM) and lens-induced myopia (LIM) in chicks. Here we examine whether coadministration with carbidopa enhances this protection and compare the effectiveness of topical versus systemic administration. We also investigate the degree to which topical and systemic administration of these compounds alters retinal dopamine release and examine whether this is the mechanism by which they inhibit experimental...[Show more]

CollectionsANU Research Publications
Date published: 2021
Type: Journal article
Source: Investigative Ophthalmology and Visual Science
DOI: 10.1167/iovs.62.4.25
Access Rights: Open Access


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