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Characterization of the effect of LPS on dendritic cell subset discrimination in spleen

Griffiths, Kristin; Tan, Jonathan; O'Neill, Helen

Description

The Gram-negative bacterial endotoxin lipopolysaccharide (LPS) is a potent inflammatory mediator and a leading cause of bacterial sepsis. While LPS is known to activate antigen-presenting cells, here we find that LPS down-regulates expression of CD11c and CD11b on splenic dendritic cell subsets, thus confounding the ability to identify these subsets following treatment. This has implications with regard to tracking the response to LPS in terms of the cell subsets involved, and should be...[Show more]

dc.contributor.authorGriffiths, Kristin
dc.contributor.authorTan, Jonathan
dc.contributor.authorO'Neill, Helen
dc.date.accessioned2015-12-07T22:53:05Z
dc.identifier.issn1582-1838
dc.identifier.urihttp://hdl.handle.net/1885/27705
dc.description.abstractThe Gram-negative bacterial endotoxin lipopolysaccharide (LPS) is a potent inflammatory mediator and a leading cause of bacterial sepsis. While LPS is known to activate antigen-presenting cells, here we find that LPS down-regulates expression of CD11c and CD11b on splenic dendritic cell subsets, thus confounding the ability to identify these subsets following treatment. This has implications with regard to tracking the response to LPS in terms of the cell subsets involved, and should be considered whenever such studies are undertaken.
dc.publisherFoundation for Cellular and Molecular Medicine
dc.rightsAuthor/s retain copyright
dc.sourceJournal of Cellular and Molecular Medicine
dc.titleCharacterization of the effect of LPS on dendritic cell subset discrimination in spleen
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume18
dc.date.issued2014
local.identifier.absfor110704 - Cellular Immunology
local.identifier.absfor110799 - Immunology not elsewhere classified
local.identifier.ariespublicationu4008405xPUB53
local.type.statusPublished Version
local.contributor.affiliationGriffiths, Kristin, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationTan, Jonathan, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationO'Neill, Helen, College of Medicine, Biology and Environment, ANU
local.bibliographicCitation.issue9
local.bibliographicCitation.startpage1908
local.bibliographicCitation.lastpage1912
local.identifier.doi10.1111/jcmm.12332
local.identifier.absseo910108 - Monetary Policy
dc.date.updated2015-12-07T12:36:23Z
local.identifier.scopusID2-s2.0-84908246041
local.identifier.thomsonID000342980100020
dcterms.accessRightsOpen Access
CollectionsANU Research Publications

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