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Ptpn2 and KLRG1 regulate the generation and function of tissue-resident memory CD8 + T cells in skin

Hochheiser, Katherina; Wiede, Florian; Wagner, Teagan; Freestone, David; Enders, Matthias H; Olshansky, Moshe; Russ, Brendan; Nüssing, Simone; Bawden, Emma; Braun, Asolina; Tscharke, David


Tissue-resident memory T cells (T cells) are key elements of tissue immunity. Here, we investigated the role of the regulator of T cell receptor and cytokine signaling, Ptpn2, in the formation and function of T cells in skin. Ptpn2-deficient CD8 T cells displayed a marked defect in generating CD69 CD103 T cells in response to herpes simplex virus type 1 (HSV-1) skin infection. This was accompanied by a reduction in the proportion of KLRG1 memory precursor cells and a transcriptional bias...[Show more]

CollectionsANU Research Publications
Date published: 2021
Type: Journal article
Source: Journal of Experimental Medicine
DOI: 10.1084/jem.20200940
Access Rights: Open Access


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