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Direct priming of CD8+ T cells persists in the face of cowpox virus inhibitors of antigen presentation

Lin, Leon; Croft, Sarah; Croft, Nathan; Wong, Yik Chun; Smith, Stewart; Tang, SweeSeong; Purcell, Anthony; Tscharke, David


Vaccinia virus (VACV) was the vaccine used to eradicate smallpox and is being repurposed as a vaccine vector. CD8+ T cells are key antiviral mediators but require priming to become effector or memory cells. Priming requires an interaction with dendritic cells that are either infected (direct priming) or have acquired virus proteins but remain uninfected (cross priming). To investigate CD8+ T cell priming pathways for VACV, we engineered the virus to express CPXV12 and CPXV203, two inhibitors of...[Show more]

CollectionsANU Research Publications
Date published: 2021
Type: Journal article
Source: Journal of Virology
DOI: 10.1128/JVI.00186-21
Access Rights: Open Access


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