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Disruption of entire Cables2 locus leads to embryonic lethality by diminished Rps21 gene expression and enhanced p53 pathway

Dinh, Tra Thi Huong; Iseki, Hiroyoshi; Mizuno, Seiya; Iijima-Mizuno, Saori; Tanimoto, Yoko; Daitoku, Yoko; Kato, Kanako; Hamada, Yuko; Hasan, Ammar Shaker Hamed; Suzuki, Hayate; Arkell, Ruth


In vivo function of CDK5 and Abl enzyme substrate 2 (Cables2), belonging to the Cables protein family, is unknown. Here, we found that targeted disruption of the entire Cables2 locus (Cables2d) caused growth retardation and enhanced apoptosis at the gastrulation stage and then induced embryonic lethality in mice. Comparative transcriptome analysis revealed disruption of Cables2, 50% down-regulation of Rps21 abutting on the Cables2 locus, and up-regulation of p53-target genes in Cables2d...[Show more]

CollectionsANU Research Publications
Date published: 2021
Type: Journal article
Source: eLife
DOI: 10.7554/eLife.50346
Access Rights: Open Access


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