A point mutation in IKAROS ZF1 causes a B cell deficiency in mice
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Boast, Brigette; Miosge, Lisa; Kuehn, Hye Sun; Cho, Vicky; Athanasopoulos, Vicki; McNamara, Hayley; Sontani, Yovina; Mei, Angela (Yan); Howard, Debbie; Sutton, Harry; Omari, Sofia; Yu, Zhijia; Nasreen, Mariam; Andrews, Daniel; Cockburn, Ian; Goodnow, Christopher; Rosenzweig, Sergio D; Enders, Anselm
Description
IKZF1 (IKAROS) is essential for normal lymphopoiesis in both humans and mice. Previous Ikzf1 mouse models have demonstrated the dual role for IKZF1 in both B and T cell development and have indicated differential requirements of each zinc finger. Furthermore, mutations in IKZF1 are known to cause common variable immunodeficiency in patients characterized by a loss of B cells and reduced Ab production. Through N-ethyl-N-nitrosourea mutagenesis, we have discovered a novel Ikzf1 mutant mouse with...[Show more]
Collections | ANU Research Publications |
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Date published: | 2021 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/276183 |
Source: | Journal of Immunology |
DOI: | 10.4049/jimmunol.1901464 |
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