MS4A4B Is a GITR-Associated Membrane Adapter, Expressed by Regulatory T Cells, Which Modulates T Cell Activation
Howie, Duncan; Nolan, Kathleen F.; Daley, Stephen; Butterfield, Emma; Adams, Elisabeth; Garcia-Rueda, Hugo; Thompson, Claire; Saunders, Nigel J; Cobbold, Stephen P; Tone, Yukiko; Tone, Masahide; Waldmann, Hermann
In the aftermath of thymic negative selection, natural and adaptive regulatory T cells (Tregs) must acknowledge peripheral, "danger-free" self-Ag to ensure their sustained activity. In this paper, we show that natural and adaptive Tregs or T cells transduced with cDNA for Foxp3, just like Th1 cells, express members of the MS4A family of transmembrane molecules. Naive T cells transduced with MS4A4B become able to respond to lower levels of Ag. Using two family members, MS4A4B and MS4A6B, as...[Show more]
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