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Forager and farmer evolutionary adaptations to malaria evidenced by 7000 years of thalassemia in Southeast Asia

Vlok, Melandri; Buckley, Hallie R; Miszkiewicz, Justyna; Walker, Meg; Domett, Kate; Willis, Anna; Trinh, Hiep Hoang; Minh, Tran Thi; Nguyen, Mai Huong T.; Nguyen, Lan Cuong; Matsumura, H; Wang, Tianyi; Oxenham, Marc


Thalassemias are inherited blood disorders that are found in high prevalences in the Mediterranean, Southeast Asia and the Pacific. These diseases provide varying levels of resistance to malaria and are proposed to have emerged as an adaptive response to malaria in these regions. The transition to agriculture in the Holocene has been suggested to have influenced the selection for thalassemia in the Mediterranean as land clearance for farming encouraged interaction between Anopheles mosquitos,...[Show more]

CollectionsANU Research Publications
Date published: 2021
Type: Journal article
Source: Scientific Reports
DOI: 10.1038/s41598-021-83978-4
Access Rights: Open Access


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