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Breakdown in membrane asymmetry regulation leads to monocyte recognition of P. falciparum-infected red blood cells

Fraser, Merryn; Jing, Weidong; Broer, Stefan; Kurth, Florian; Sander, Leif E; Matuschewski, Kai; Maier, Alexander

Description

The human malaria parasite Plasmodium falciparum relies on lipids to survive; this makes its lipid metabolism an attractive drug target. The lipid phosphatidylserine (PS) is usually confined to the inner leaflet of the red blood cell membrane (RBC) bilayer; however, some studies suggest that infection with the intracellular parasite results in the presence of this lipid in the RBC membrane outer leaflet, where it could act as a recognition signal to phagocytes. Here, we used fluorescent lipid...[Show more]

CollectionsANU Research Publications
Date published: 2021
Type: Journal article
URI: http://hdl.handle.net/1885/276078
Source: PLoS Pathogens
DOI: 10.1371/journal.ppat.1009259
Access Rights: Open Access

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