Faux, Noel G; Huttley, Gavin Austin; Mahmood, Khalid; Webb, Geoffrey Ian; Garcia de la Banda, Maria; Whisstock, James C
Over 3% of human proteins contain single amino acid repeats (repeat-containing proteins, RCPs). Many repeats (homopeptides) localize to important proteins involved in transcription, and the expansion of certain repeats, in particular poly-Q and poly-A tracts, can also lead to the development of neurological diseases. Previous studies have suggested that the homopeptide makeup is a result of the presence of G+C-rich tracts in the encoding genes and that expansion occurs via replication slippage....[Show more]
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