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Effects of Sepiapterin Supplementation and NOS Inhibition on Glucocorticoid-Induced Hypertension

Thida, Mya; Earl, John; Zhao, Yan; Wang, Hans; Tse, Chi-Sum (Sammy); Vickers, Janine; Sutton, Matthew; Mori, Trevor A; Ong, Sharon; Croft, Kevin D; Whitworth, Judith; Zhang, Yi


Glucocorticoid-induced hypertension is associated with imbalance between nitric oxide (NO) and superoxide. One of the pathways that causes this imbalance is endothelial NO synthase (eNOS) uncoupling. In the present study, adrenocorticotrophic hormone (ACTH)-and dexamethasone-treated rats were further treated with sepiapterin, a precursor of tetrahydrobiopterin, or N-nitro-L-arginine (NOLA), an inhibitor of NOS, to investigate the role of eNOS uncoupling in glucocorticoid-induced...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: American Journal of Hypertension
DOI: 10.1038/ajh.2010.27


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