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Unique levels of expression of N-methyl-D-aspartate receptor subunits and neuronal nitric oxide synthase in the rostral ventrolateral medulla of the spontaneously hypertensive rat

Edwards, Mark; Loxley, Rhonda; Powers-Martin, Kellysan; Lipski, Janusz; McKitrick, D.J; Arnolda, Leonard; Phillips, Jacqueline


The rostral ventrolateral medulla (RVLM) is the major brainstem region contributing to sympathetic control of blood pressure. We have compared the expression of N-methyl-D-aspartate (NMDA) receptor subunits (NR1, NR2A-D), NR1 splice variants (NR1-1a/1b, -2a/2b, -3a/3b, -4a/4b), and the neuronal and inducible isoforms of NO synthase (nNOS and iNOS) in the RVLM of Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHR), based on the hypothesis that altered NMDA receptor make-up or altered...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Molecular Brain Research
DOI: 10.1016/j.molbrainres.2004.06.013


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