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The Effects of the Alkaloid Tambjamine J on Mice Implanted with Sarcoma 180 Tumor Cells

Barros-Nepomuceno, Francisco Washington; Viana, Daniel de Araujo; Pinheiro, Daniel Pascoalino; de Oliveira, Fatima de Cassia Evangelista; Ferreira, Jamile Magalhaes; de Queiroz, Maria Goretti; Ma, Xing; Cavalcanti, Bruno Coelho; Pessoa, Claudia; Banwell, Martin

Description

The tambjamines are a small group of bipyrrolic alkaloids that, collectively, display a significant range of biological activities including antitumor, antimicrobial and immunosuppressive properties. The key objective of the present study was to undertake preclinical assessments of tambjamine J (T‐J) so as to determine its in vivo antitumor effects. To that end, sarcoma 180 cells were transplanted in mice and the impacts of the title compound then evaluated using a range of protocols including...[Show more]

dc.contributor.authorBarros-Nepomuceno, Francisco Washington
dc.contributor.authorViana, Daniel de Araujo
dc.contributor.authorPinheiro, Daniel Pascoalino
dc.contributor.authorde Oliveira, Fatima de Cassia Evangelista
dc.contributor.authorFerreira, Jamile Magalhaes
dc.contributor.authorde Queiroz, Maria Goretti
dc.contributor.authorMa, Xing
dc.contributor.authorCavalcanti, Bruno Coelho
dc.contributor.authorPessoa, Claudia
dc.contributor.authorBanwell, Martin
dc.date.accessioned2022-10-05T01:29:47Z
dc.identifier.issn1860-7179
dc.identifier.urihttp://hdl.handle.net/1885/274296
dc.description.abstractThe tambjamines are a small group of bipyrrolic alkaloids that, collectively, display a significant range of biological activities including antitumor, antimicrobial and immunosuppressive properties. The key objective of the present study was to undertake preclinical assessments of tambjamine J (T‐J) so as to determine its in vivo antitumor effects. To that end, sarcoma 180 cells were transplanted in mice and the impacts of the title compound then evaluated using a range of protocols including hematological, biochemical, histopathological, genotoxic and clastogenic assays. As a result it was established that this alkaloid has a significant therapeutic window and effectively reduces tumor growth (by 40 % and 79 % at doses of 10 and 20 mg/kg/day, respectively). In this regard it displays similar antitumor activity to the anticancer agent cyclophosphamide and alters animal weight in an analogous manner.
dc.description.sponsorshipThe study was financed in part by the Coordenação de Aperfeiçoamento Pessoalde NívelSuperior– Brasil(CAPES)(Finance Code 001-Capes Print Process nr. 8887311918/2018-00).The authors are also grateful to Conselho Nacionalde Desenvolvi-mento Científico e Tecnológico– CNPq for financial support(Process nr. 440755/2018-2)as well as research sponsorship of CP(PQ-1B Process nr. 303102/2013-6).The Australian Research Council is thanked for variousgrantsand fellowships.
dc.format.mimetypeapplication/pdf
dc.language.isoen_AU
dc.publisherWiley
dc.rights© 2020 Wiley-VCHGmbH
dc.sourceChemMedChem
dc.titleThe Effects of the Alkaloid Tambjamine J on Mice Implanted with Sarcoma 180 Tumor Cells
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume16
dc.date.issued2021
local.identifier.absfor000000 - Internal ANU use only
local.identifier.ariespublicationa383154xPUB15318
local.publisher.urlhttps://www.wiley.com/en-gb
local.type.statusPublished Version
local.contributor.affiliationBarros-Nepomuceno, Francisco Washington, University for International Integration of the Afro-Brazilian Lusophony
local.contributor.affiliationViana, Daniel de Araujo, Pathological Anatomy and Veterinary Clinic
local.contributor.affiliationPinheiro, Daniel Pascoalino, Federal University of Ceara
local.contributor.affiliationde Oliveira, Fatima de Cassia Evangelista, Federal University of Ceara
local.contributor.affiliationFerreira, Jamile Magalhaes, University for International Integration of the Afro-Brazilian Lusophony
local.contributor.affiliationde Queiroz, Maria Goretti, Federal University of Ceara
local.contributor.affiliationMa, Xing, College of Science, ANU
local.contributor.affiliationCavalcanti, Bruno Coelho, University for International Integration of the Afro-Brazilian Lusophony
local.contributor.affiliationPessoa, Claudia, Universidade Federal do Ceara
local.contributor.affiliationBanwell, Martin, College of Science, ANU
local.description.embargo2099-12-31
local.bibliographicCitation.startpage420
local.bibliographicCitation.lastpage428
local.identifier.doi10.1002/cmdc.202000387
dc.date.updated2021-11-28T07:21:13Z
local.identifier.scopusID2-s2.0-85093844082
CollectionsANU Research Publications

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