The Effects of the Alkaloid Tambjamine J on Mice Implanted with Sarcoma 180 Tumor Cells
Barros-Nepomuceno, Francisco Washington; Viana, Daniel de Araujo; Pinheiro, Daniel Pascoalino; de Oliveira, Fatima de Cassia Evangelista; Ferreira, Jamile Magalhaes; de Queiroz, Maria Goretti; Ma, Xing; Cavalcanti, Bruno Coelho; Pessoa, Claudia; Banwell, Martin
The tambjamines are a small group of bipyrrolic alkaloids that, collectively, display a significant range of biological activities including antitumor, antimicrobial and immunosuppressive properties. The key objective of the present study was to undertake preclinical assessments of tambjamine J (T‐J) so as to determine its in vivo antitumor effects. To that end, sarcoma 180 cells were transplanted in mice and the impacts of the title compound then evaluated using a range of protocols including...[Show more]
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