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rDNA Chromatin Activity Status as a Biomarker of Sensitivity to the RNA Polymerase I Transcription Inhibitor CX-5461

Son, Jinbae; Hannan, Kate; Poortinga, Gretchen; Hein, Nadine; Cameron, Donald; Ganley, Austen R. D.; Sheppard, Karen E.; Pearson, Richard B.; Hannan, Ross; Sanij, Elaine


Hyperactivation of RNA polymerase I (Pol I) transcription of ribosomal RNA (rRNA) genes (rDNA) is a key determinant of growth and proliferation and a consistent feature of cancer cells. We have demonstrated that inhibition of rDNA transcription by the Pol I transcription inhibitor CX-5461 selectively kills tumor cells in vivo. Moreover, the first-in human trial of CX-5461 has demonstrated CX-5461 is well-tolerated in patients and has single-agent anti-tumor activity in hematologic malignancies....[Show more]

CollectionsANU Research Publications
Date published: 2020-07-03
Type: Journal article
Source: Frontiers in Cell and Developmental Biology
DOI: 10.3389/fcell.2020.00568
Access Rights: Open Access


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