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Release of promoter-proximal paused Pol II in response to histone deacetylase inhibition

Vaid, Roshan; Wen, Jiayu; Mannervik, Mattias


A correlation between histone acetylation and transcription has been noted for a long time, but little is known about what step(s) in the transcription cycle is influenced by acetylation. We have examined the immediate transcriptional response to histone deacetylase (HDAC) inhibition, and find that release of promoter-proximal paused RNA polymerase II (Pol II) into elongation is stimulated, whereas initiation is not. Although histone acetylation is elevated globally by HDAC inhibition, less...[Show more]

CollectionsANU Research Publications
Date published: 2020-04-16
Type: Journal article
Source: Nucleic Acids Research
DOI: 10.1093/nar/gkaa234
Access Rights: Open Access


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