Antibody Feedback Limits the Expansion of B Cell Responses to Malaria Vaccination but Drives Diversification of the Humoral Response
McNamara, Hayley; Idris, Azza; Sutton, Harry; Vistein, Rachel; Flynn, Barbara; Cai, Yeping; Wiehe, Kevin; Lyke, Kirsten; Chatterjee, Deepyan; KC, Natasha; Chakravarty, Sumana; Kim Lee Sim, B.; Hoffman, Stephen L; Bonsignori, Mattia; Seder, Robert; Cockburn, Ian
Generating sufficient antibody to block infection is a key challenge for vaccines against malaria. Here, we show that antibody titers to a key target, the repeat region of the Plasmodium falciparum circumsporozoite protein (PfCSP), plateaued after two immunizations in a clinical trial of the radiation-attenuated sporozoite vaccine. To understand the mechanisms limiting vaccine responsiveness, we developed immunoglobulin (Ig)-knockin mice with elevated numbers of PfCSP-binding B cells. We...[Show more]
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|Source:||Cell Host and Microbe|
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