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Quantitative analysis of HP1alpha binding to nucleosomal arrays

Fan, Jun; Zhou, Jiansheng; Tremethick, David

Description

Elucidating how the metazoan genome is organised into distinct functional domains is fundamental to understanding all aspects of normal cellular growth and development. The "histone code" hypothesis predicts that post-translational modifications of specific histone residues regulate genomic function by selectively recruiting nuclear factors that modify chromatin structure. A paradigm supporting this hypothesis is the preferential binding of the silencing protein heterochromatin protein 1 (HP1)...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
URI: http://hdl.handle.net/1885/27414
Source: Methods
DOI: 10.1016/j.ymeth.2006.11.001

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