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Multistep pathogenesis of autoimmune disease

Goodnow, Christopher


In the immune system, many tolerance checkpoints exist to prevent self-antigens from stimulating the relentless growth of self-reactive B and T lymphocytes. The genes and molecular pathways underpinning these checkpoints overlap with those involved in tumor suppression. As with an inherited predisposition to cancer, inherited defects in self-tolerance genes typically precipitate autoimmune disease stochastically after a latent phase. Multiple mutations, inherited and somatic, may be needed...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Cell
DOI: 10.1016/j.cell.2007.06.033


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