Skip navigation
Skip navigation

Multistep pathogenesis of autoimmune disease

Goodnow, Christopher


In the immune system, many tolerance checkpoints exist to prevent self-antigens from stimulating the relentless growth of self-reactive B and T lymphocytes. The genes and molecular pathways underpinning these checkpoints overlap with those involved in tumor suppression. As with an inherited predisposition to cancer, inherited defects in self-tolerance genes typically precipitate autoimmune disease stochastically after a latent phase. Multiple mutations, inherited and somatic, may be needed...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Cell
DOI: 10.1016/j.cell.2007.06.033


File Description SizeFormat Image
01_Goodnow_Multistep_pathogenesis_of_2007.pdf1.29 MBAdobe PDF    Request a copy

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  20 July 2017/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator