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Allergic sensitization is enhanced in early life through toll-like receptor 7 activation

Phipps, Simon; Hansbro, Nicole; Lam, Chuan En; Foo, Shen Yun; Matthaei, Klaus; Foster, Paul S


Background Prospective cohort studies suggest that children hospitalized in early life with severe infections are significantly more likely to develop recurrent wheezing and asthma. Objective Using an inhalational mouse model of allergic airways inflammation, we sought to determine the effect of viral and bacterial-associated molecular patterns on the magnitude of the allergic inflammatory response and whether this effect was age dependent. Methods BALB/c mice were sensitized by intranasal...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: Clinical and Experimental Allergy
DOI: 10.1111/j.1365-2222.2009.03335.x


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