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Plasma surfactant protein-B: a novel biomarker in chronic heart failure

De Pasquale, Carmine G; Arnolda, Leonard; DOYLE, Ian R; Aylward, Phillip; Chew, Derek; BERSTEN, Andrew


Background - in chronic heart failure (CHF), elevated pulmonary microvascular pressure (Pmv) results in pulmonary edema. Because elevated Pmv may alter the integrity of the alveolocapillary barrier, allowing leakage of surfactant protein-B (SP-B) from the alveoli into the circulation, we aimed to determine plasma levels of SP-B in CHF and their relation to clinical status. Methods and Results - Fifty-three outpatients with CHF had plasma SP-B and N-terminal proBNP (NT-proBNP) assayed, in...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Circulation Research
DOI: 10.1161/01.CIR.0000140260.73611.FA


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