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Hookworm secreted extracellular vesicles interact with host cells and prevent inducible colitis in mice

Ryan, Stephanie; Jones, Linda; Eichenberger, Ramon M; Buitrago, Geraldine; Polster, Ramona; de Oca, Marcela Montes; Zuvelek, Jennifer; Giacomin, Paul R.; Dent, Lindsay; Engwerda, Christian R; Field, Matthew; Sotillo, Javier; Loukas, Alex


Gastrointestinal (GI) parasites, hookworms in particular, have evolved to cause minimal harm to their hosts, allowing them to establish chronic infections. This is mediated by creating an immunoregulatory environment. Indeed, hookworms are such potent suppressors of inflammation that they have been used in clinical trials to treat inflammatory bowel diseases (IBD) and celiac disease. Since the recent description of helminths (worms) secreting extracellular vesicles (EVs), exosome-like EVs from...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
Source: Frontiers in Immunology
DOI: 10.3389/fimmu.2018.00850
Access Rights: Open Access


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