Skip navigation
Skip navigation

A probabilistic method to identify compensatory substitutions for pathogenic mutations

Easton, Brett; Isaev, Alexander; Huttley, Gavin Austin; Maxwell, Peter


Complex systems of interactions govern the structure and function of biomolecules. Mutations that substantially disrupt these interactions are deleterious and should not persist under selection. Yet, several instances have been reported where a variant confirmed as pathogenic in one species is fixed in the orthologs of other species. Here we introduce a novel method for detecting compensatory substitutions for these so-called compensated pathogenic deviations (CPDs), incorporating knowledge of...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Conference paper
Source: Proceedings of the 5th Asia-Pacific Bioinformatics Conference (APBC 2007)


File Description SizeFormat Image
01_Easton_A_probabilistic_method_to_2007.pdf16.12 MBAdobe PDF    Request a copy

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  17 November 2022/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator