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Coordination of Substrate Binding and Protonation in the N. gonorrhoeae MtrD Efflux Pump Controls the Functionally Rotating Transport Mechanism

Fairweather, Stephen; Gupta, Vrinda; Chitsaz, Mohsen; Booth, Lauren; Brown, Melissa; O'Mara, Megan


Multidrug resistance is a serious problem that threatens the effective treatment of the widespread sexually transmitted disease gonorrhea, caused by the Gram-negative bacterium Neisseria gonorrhoeae. The drug efflux pump primarily implicated in N. gonorrhoeae antimicrobial resistance is the inner membrane transporter MtrD, which forms part of the tripartite multiple transferable resistance (Mtr) CDE efflux system. A structure of MtrD was first solved in 2014 as a symmetrical homotrimer, and...[Show more]

CollectionsANU Research Publications
Date published: 2021
Type: Journal article
Source: ACS Infectious Diseases
DOI: 10.1021/acsinfecdis.1c00149


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