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Expression of the heparan sulfate-degrading enzyme heparanase is induced in infiltrating CD4+ T cells in experimental autoimmune encephalomyelitis and regulated at the level of transcription by early growth response gene 1

de Mestre, A; Staykova, Maria; Hornby, June; Willenborg, D; Hulett, Mark

Description

The heparan sulfate-cleaving enzyme heparanase (HPSE) plays an important role in remodeling of the basement membrane and extracellular matrix during inflammation. Inducible HPSE enzymatic activity has been reported in leukocytes; however, little is known

dc.contributor.authorde Mestre, A
dc.contributor.authorStaykova, Maria
dc.contributor.authorHornby, June
dc.contributor.authorWillenborg, D
dc.contributor.authorHulett, Mark
dc.date.accessioned2015-12-07T22:50:41Z
dc.identifier.issn0741-5400
dc.identifier.urihttp://hdl.handle.net/1885/27118
dc.description.abstractThe heparan sulfate-cleaving enzyme heparanase (HPSE) plays an important role in remodeling of the basement membrane and extracellular matrix during inflammation. Inducible HPSE enzymatic activity has been reported in leukocytes; however, little is known
dc.publisherFederation of American Societies for Experimental Biology
dc.sourceJournal of Leukocyte Biology
dc.subjectKeywords: early growth response factor 1; heparanase; messenger RNA; small interfering RNA; allergic encephalomyelitis; animal experiment; animal model; article; CD4+ T lymphocyte; CD8+ T lymphocyte; cell infiltration; central nervous system; controlled study; dise Autoimmunity; Extracellular matrix; Inflammation; Migration; Multiple sclerosis
dc.titleExpression of the heparan sulfate-degrading enzyme heparanase is induced in infiltrating CD4+ T cells in experimental autoimmune encephalomyelitis and regulated at the level of transcription by early growth response gene 1
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume82
dc.date.issued2007
local.identifier.absfor060106 - Cellular Interactions (incl. Adhesion, Matrix, Cell Wall)
local.identifier.ariespublicationu4020362xPUB49
local.type.statusPublished Version
local.contributor.affiliationde Mestre, A, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationStaykova, Maria, Canberra Hospital
local.contributor.affiliationHornby, June, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationWillenborg, D, Canberra Hospital
local.contributor.affiliationHulett, Mark, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.issue5
local.bibliographicCitation.startpage1289
local.bibliographicCitation.lastpage300
local.identifier.doi10.1189/jlb.0507315
dc.date.updated2015-12-07T12:20:31Z
local.identifier.scopusID2-s2.0-36249028186
CollectionsANU Research Publications

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