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Expression of the heparan sulfate-degrading enzyme heparanase is induced in infiltrating CD4+ T cells in experimental autoimmune encephalomyelitis and regulated at the level of transcription by early growth response gene 1

de Mestre, A; Staykova, Maria; Hornby, June; Willenborg, D; Hulett, Mark


The heparan sulfate-cleaving enzyme heparanase (HPSE) plays an important role in remodeling of the basement membrane and extracellular matrix during inflammation. Inducible HPSE enzymatic activity has been reported in leukocytes; however, little is known

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Journal of Leukocyte Biology
DOI: 10.1189/jlb.0507315


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