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Toll-Interleukin-1 signalling is critical for house mite-specific th2 and th17 responses

Phipps, Simon; Lam, Chuan En; Kaiko, Gerard E; Foo, Shen Yun; Collison, Adam; Mattes, Joerg; Barry, Jessica; Davidson, Sophia; Oreo, Kevin; Smith, Lauren; Mansell, Ashley; Matthaei, Klaus; Foster, Paul S


Rationale: One of the immunopathological features of allergic inflammation is the infiltration of helper T type 2 (Th2) cells to the site of disease. Activation of innate pattern recognition receptors such as Toll-like receptors (TLRs) plays a critical role in helper T type 1 cell differentiation, yet their contribution to the generation of Th2 responses to clinically relevant aeroallergens remains poorly defined. Objectives: To determine the requirement for TLR2, TLR4, and the Toll/IL-1...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: American Journal of Respiratory and Critical Care Medicine
DOI: 10.1164/rccm.200806-974OC


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