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Aryl urea substituted fatty acids: A new class of protonophoric mitochondrial uncoupler that utilises a synthetic anion transporter

Rawling, Tristan; MacDermott-Opeskin, Hugo; Roseblade, A; Pazderka, C; Clarke, C; Bourget, K; Wu, X; Lewis, W; Noble, Dr Benjamin; Gale, P A; O'Mara, Megan; Cranfield, C; Murray, M


Respiring mitochondria establish a proton gradient across the mitochondrial inner membrane (MIM) that is used to generate ATP. Protein-independent mitochondrial uncouplers collapse the proton gradient and disrupt ATP production by shuttling protons back across the MIM in a protonophoric cycle. Continued cycling relies on the formation of MIM-permeable anionic species that can return to the intermembrane space after deprotonation in the mitochondrial matrix. Previously described protonophores...[Show more]

CollectionsANU Research Publications
Date published: 2020
Type: Journal article
Source: Chemical Science
DOI: 10.1039/d0sc02777d
Access Rights: Open Access


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