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Inhibition of microRNA-155 Protects Retinal Function Through Attenuation of Inflammation in Retinal Degeneration

Aggio-Bruce, Riemke; Chu-Tan, Joshua; Wooff, Yvette; Cioanca, Adrian; Schumann, Ulrike; Natoli, Riccardo


Although extensively investigated in inflammatory conditions, the role of pro-inflammatory microRNAs (miRNAs), miR-155 and miR-146a, has not been well-studied in retinal degenerative diseases. We therefore aimed to explore the role and regulation of these miRNA in the degenerating retina, with a focus on miR-155. C57BL/6J mice were subjected to photo-oxidative damage for up to 5 days to induce focal retinal degeneration. MiR-155 expression was quantified by qRT-PCR in whole retina,...[Show more]

CollectionsANU Research Publications
Date published: 2021
Type: Journal article
Source: Molecular Neurobiology
DOI: 10.1007/s12035-020-02158-z
Access Rights: Open Access


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