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Synthesis of thioridazine-VLA-4 antagonist hybrids using N-propargyl northioridazine enantiomers

Martyn, A. P.; Willis, Anthony; Kelso, Michael


Herein, we report the synthesis of thioridazine-VLA-4 hybrid epimers. These hybrid molecules were obtained by means of a click reaction involving N-propargyl northioridazine enantiomers and an azide containing VLA-4 antagonist. A synthesis of northioridazine enantiomers from racemic thioridazine was developed and the absolute stereochemistry was confirmed by X-ray crystallography. Access to N-substituted thioridazine analogs may reveal that this phenothiazine core has therapeutic potential in...[Show more]

CollectionsANU Research Publications
Date published: 2020
Type: Journal article
Source: Synthetic Communications
DOI: 10.1080/00397911.2020.1785503


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