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Effect of anaesthetic and rat strain on heart rate responses to simulated haemorrhage

Holobotovskyy, V.V.; Arnolda, Leonard; McKitrick, D.J

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Aim and methods: Haemorrhage is characterized by two distinct responses, sympathoexcitation that evokes tachycardia and supports blood pressure, followed by sympathoinhibition contributing to bradycardia and hypotension. It has been shown that anaesthetics alter the response to haemorrhage and we hypothesized that rat strain may also influence the response. We investigated the effect of simulated haemorrhage on heart rate (HR) responses in three strains of conscious rats, and the effect of...[Show more]

dc.contributor.authorHolobotovskyy, V.V.
dc.contributor.authorArnolda, Leonard
dc.contributor.authorMcKitrick, D.J
dc.date.accessioned2015-12-07T22:50:20Z
dc.identifier.issn0001-6772
dc.identifier.urihttp://hdl.handle.net/1885/26984
dc.description.abstractAim and methods: Haemorrhage is characterized by two distinct responses, sympathoexcitation that evokes tachycardia and supports blood pressure, followed by sympathoinhibition contributing to bradycardia and hypotension. It has been shown that anaesthetics alter the response to haemorrhage and we hypothesized that rat strain may also influence the response. We investigated the effect of simulated haemorrhage on heart rate (HR) responses in three strains of conscious rats, and the effect of three common anaesthetics, by comparing HR responses under anaesthesia to the conscious response. Haemorrhage was simulated by constricting the inferior vena cava. We demonstrate differential effects of anaesthetics, including both maintenance and elimination of HR responses to haemorrhage depending on anaesthetic. Results: We also show that both phases of the HR response differ in different conscious rat strains, and we have demonstrated a transient increase in HR during the decompensatory phase of haemorrhage, a novel 'second HR peak' with advanced hypotension. Conclusion: Both rat strain and anaesthetic influence HR responses to haemorrhage, and some anaesthetics appear less suitable than others for studies of haemodynamic responses in rats. There was evidence of an additional compensatory mechanism that operates at advanced levels of hypotension in the rat.
dc.publisherWiley-Blackwell
dc.sourceActa Physiologica
dc.subjectKeywords: anesthesia; animal experiment; animal model; article; bleeding; controlled study; heart rate; hemodynamic monitoring; hypotension; inferior cava vein obstruction; male; nonhuman; priority journal; rat; rat strain; simulation; Anesthetics; Anesthetics, Inh Barbiturate; Halothane; Simulated haemorrhage; Spontaneously hypertensive rat; Sprague-Dawley rat; Urethane; Wistar-Kyoto rat
dc.titleEffect of anaesthetic and rat strain on heart rate responses to simulated haemorrhage
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume180
dc.date.issued2004
local.identifier.absfor110299 - Cardiovascular Medicine and Haematology not elsewhere classified
local.identifier.ariespublicationu4201517xPUB48
local.type.statusPublished Version
local.contributor.affiliationHolobotovskyy, V.V., University of Western Australia
local.contributor.affiliationArnolda, Leonard, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationMcKitrick, D.J, University of Western Australia
local.description.embargo2037-12-31
local.bibliographicCitation.startpage29
local.bibliographicCitation.lastpage38
local.identifier.doi10.1046/j.0001-6772.2003.01218.x
dc.date.updated2015-12-07T12:16:43Z
local.identifier.scopusID2-s2.0-0842329763
CollectionsANU Research Publications

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