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Effect of anaesthetic and rat strain on heart rate responses to simulated haemorrhage

Holobotovskyy, V.V.; Arnolda, Leonard; McKitrick, D.J


Aim and methods: Haemorrhage is characterized by two distinct responses, sympathoexcitation that evokes tachycardia and supports blood pressure, followed by sympathoinhibition contributing to bradycardia and hypotension. It has been shown that anaesthetics alter the response to haemorrhage and we hypothesized that rat strain may also influence the response. We investigated the effect of simulated haemorrhage on heart rate (HR) responses in three strains of conscious rats, and the effect of...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Acta Physiologica
DOI: 10.1046/j.0001-6772.2003.01218.x


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