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Regulation of mouse Heparanase gene expression in T lymphocytes and tumor cells

de Mestre, A; Soe-Htwe, Thura; Sutcliffe, Elissa; Rao, Sudha; Pagler, Eloisa; Hornby, June; Hulett, Mark


Heparanase (HPSE) is an endoglycosidase that cleaves heparan sulfate (HS) and plays an important role in tumor metastasis, angiogenesis and inflammation. The regulation of HPSE expression and function is tightly controlled and the increasing use of the mouse as an animal model to define the role of HPSE in many physiological and pathological settings, makes understanding the regulatory mechanisms of HPSE in this species of fundamental importance. However, the expression distribution of the...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Immunology and Cell Biology
DOI: 10.1038/sj.icb.7100022


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