Skip navigation
Skip navigation

Diverse chemotypes disrupt ion homeostasis in the malaria parasite

Lehane, Adele; Ridgway, Melanie; Baker, Eileen; Kirk, Kiaran


The antimalarial spiroindolones disrupt Plasmodium falciparumNa+ regulation and induce an alkalinization of the parasite cytosol. It has been proposed that they do so by inhibiting PfATP4, a parasite plasma membrane P-type ATPase postulated to export Na+

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: Molecular Microbiology
DOI: 10.1111/mmi.12765


File Description SizeFormat Image
01_Lehane_Diverse_chemotypes_disrupt_ion_2014.pdf935.78 kBAdobe PDFThumbnail

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator