Diverse chemotypes disrupt ion homeostasis in the malaria parasite
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Lehane, Adele; Ridgway, Melanie; Baker, Eileen; Kirk, Kiaran
Description
The antimalarial spiroindolones disrupt Plasmodium falciparumNa+ regulation and induce an alkalinization of the parasite cytosol. It has been proposed that they do so by inhibiting PfATP4, a parasite plasma membrane P-type ATPase postulated to export Na+
| Collections | ANU Research Publications |
|---|---|
| Date published: | 2014 |
| Type: | Journal article |
| URI: | http://hdl.handle.net/1885/26961 |
| Source: | Molecular Microbiology |
| DOI: | 10.1111/mmi.12765 |
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| File | Description | Size | Format | Image |
|---|---|---|---|---|
| 01_Lehane_Diverse_chemotypes_disrupt_ion_2014.pdf | 935.78 kB | Adobe PDF |  |
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