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Diverse chemotypes disrupt ion homeostasis in the malaria parasite

Lehane, Adele; Ridgway, Melanie; Baker, Eileen; Kirk, Kiaran


The antimalarial spiroindolones disrupt Plasmodium falciparumNa+ regulation and induce an alkalinization of the parasite cytosol. It has been proposed that they do so by inhibiting PfATP4, a parasite plasma membrane P-type ATPase postulated to export Na+

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: Molecular Microbiology
DOI: 10.1111/mmi.12765


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