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Dynamics of plasma proteome during leptin-replacement therapy in genetically based leptin deficiency

Andreev, V P; Dwivedi, R C; Da Paz Filho, Gilberto; Krokhin, O V; Wong, Ma-Li; Wilkins, J A; Licinio, Julio


The effects of leptin-replacement therapy on the plasma proteome of three unique adults with genetically based leptin deficiency were studied longitudinally during the course of recombinant human leptin-replacement treatment. Quantitative proteomics analysis was performed in plasma samples collected during four stages: before leptin treatment was initiated, after 1.5 and 6 years of leptin-replacement treatment, and after 7 weeks of temporary interruption of leptin-replacement therapy. Of 500...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Pharmacogenomics Journal
DOI: 10.1038/tpj.2010.30


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