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Macromolecular modeling and design in Rosetta: recent methods and frameworks

Koehler Leman, Julia; Weitzner, Brian D.; Lewis, Steven M.; Adolf-Bryfogle, Jared; Alam, Nawsad; Alford, Rebecca F.; Aprahamian, Melanie; Baker, David; Barlow, Kyle A.; Barth, Patrick; Basanta, Benjamin; Bender, Brian J.; Blacklock, Kristin; Bonet, Jaume; Boyken, Scott E.; Huber, Thomas; Pilla, Kala


The Rosetta software for macromolecular modeling, docking and design is extensively used in laboratories worldwide. During two decades of development by a community of laboratories at more than 60 institutions, Rosetta has been continuously refactored and extended. Its advantages are its performance and interoperability between broad modeling capabilities. Here we review tools developed in the last 5 years, including over 80 methods. We discuss improvements to the score function, user...[Show more]

CollectionsANU Research Publications
Date published: 2020-06-01
Type: Journal article
Source: Nature Methods: techniques for life scientists and chemists
DOI: 10.1038/s41592-020-0848-2


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