Sparse grids and hybrid methods for the chemical master equation
The direct numerical solution of the chemical master equation (CME) is usually impossible due to the high dimension of the computational domain. The standard method for solution of the equation is to generate realizations of the chemical system by the stochastic simulation algorithm (SSA) by Gillespie and then taking averages over the trajectories. Two alternatives are described here using sparse grids and a hybrid method. Sparse grids, implemented as a combination of aggregated grids are used...[Show more]
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