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Regulation of Carcinogenesis by IL-5 and CCL11: A Potential Role for Eosinophils in Tumor Immune Surveillance

Simson, Ljubov; Ellyard, Julia; Dent, Lindsay; Matthaei, Klaus; Rothenberg, Marc E; Foster, Paul S; Smyth, Mark J; Parish, Christopher


The role of the immune system in the surveillance of transformed cells has seen a resurgence of interest in the last 10 years, with a substantial body of data in mice and humans supporting a role for the immune system in host protection from tumor development and in shaping tumor immunogenicity. A number of earlier studies have demonstrated that eosinophils, when recruited into tumors, can very effectively eradicate transplantable tumors. In this study, we investigated whether eosinophils also...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Journal of Immunology


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