New evidence for p-gp-mediated export of amyloid-β peptides in molecular, blood-brain barrier and neuronal models
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Chai, Amanda B.; Hartz, Anika M. S.; Gao, Xuexin; Yang, Alryel; Callaghan, Richard
Description
Defective clearance mechanisms lead to the accumulation of amyloid-beta (Aβ) peptides in the Alzheimer's brain. Though predominantly generated in neurons, little is known about how these hydrophobic, aggregation-prone, and tightly membrane-associated peptides exit into the extracellular space where they deposit and propagate neurotoxicity. The ability for P-glycoprotein (P-gp), an ATP-binding cassette (ABC) transporter, to export Aβ across the blood-brain barrier (BBB) has previously been...[Show more]
Collections | ANU Research Publications |
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Date published: | 2021 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/267413 |
Source: | International Journal of Molecular Sciences |
DOI: | 10.3390/ijms22010246 |
Access Rights: | Open Access |
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01_Chai_New_evidence_for_p-gp-mediated_2021.pdf | 1.49 MB | Adobe PDF |
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