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New evidence for p-gp-mediated export of amyloid-β peptides in molecular, blood-brain barrier and neuronal models

Chai, Amanda B.; Hartz, Anika M. S.; Gao, Xuexin; Yang, Alryel; Callaghan, Richard


Defective clearance mechanisms lead to the accumulation of amyloid-beta (Aβ) peptides in the Alzheimer's brain. Though predominantly generated in neurons, little is known about how these hydrophobic, aggregation-prone, and tightly membrane-associated peptides exit into the extracellular space where they deposit and propagate neurotoxicity. The ability for P-glycoprotein (P-gp), an ATP-binding cassette (ABC) transporter, to export Aβ across the blood-brain barrier (BBB) has previously been...[Show more]

CollectionsANU Research Publications
Date published: 2021
Type: Journal article
Source: International Journal of Molecular Sciences
DOI: 10.3390/ijms22010246
Access Rights: Open Access


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