Psoriasis and infection. A clinical practice narrative
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Rademaker, Marius; Agnew, Karen; Anagnostou, Nicholas; Andrews, Megan; Armour, Katherine; Baker, Christopher M.; Foley, P.; Gebauer, Kurt; Gupta, Monisha; Marshman, Gillian; Rubel, Diana; Sullivan, John; Won, Li-Chuen
Description
The Australasian Psoriasis Collaboration has developed a clinical practice narrative with respect to the relationship between psoriasis, its treatment and infection. The cutaneous microbiome of patients with psoriasis is different to those without psoriasis, although the significance of this is unclear. Whilst a wide range of microorganisms has been associated with psoriasis (including β‐haemolytic streptococci, Staphylococcus aureus, Porphyromonas gingivalis, Candida albicans, Chlamydia...[Show more]
dc.contributor.author | Rademaker, Marius | |
---|---|---|
dc.contributor.author | Agnew, Karen | |
dc.contributor.author | Anagnostou, Nicholas | |
dc.contributor.author | Andrews, Megan | |
dc.contributor.author | Armour, Katherine | |
dc.contributor.author | Baker, Christopher M. | |
dc.contributor.author | Foley, P. | |
dc.contributor.author | Gebauer, Kurt | |
dc.contributor.author | Gupta, Monisha | |
dc.contributor.author | Marshman, Gillian | |
dc.contributor.author | Rubel, Diana | |
dc.contributor.author | Sullivan, John | |
dc.contributor.author | Won, Li-Chuen | |
dc.date.accessioned | 2022-06-19T23:24:03Z | |
dc.identifier.issn | 0004-8380 | |
dc.identifier.uri | http://hdl.handle.net/1885/267371 | |
dc.description.abstract | The Australasian Psoriasis Collaboration has developed a clinical practice narrative with respect to the relationship between psoriasis, its treatment and infection. The cutaneous microbiome of patients with psoriasis is different to those without psoriasis, although the significance of this is unclear. Whilst a wide range of microorganisms has been associated with psoriasis (including β‐haemolytic streptococci, Staphylococcus aureus, Porphyromonas gingivalis, Candida albicans, Chlamydia psittaci, human immunodeficiency virus and hepatitis C virus), there is limited evidence that antimicrobial therapy is of direct benefit in preventing flares of psoriasis. Psoriasis is independently associated with an increased risk of serious infection, but the absolute risk is low. The risk of serious infections is further increased with immune‐modulatory treatments. The decision whether to, and when to, stop or resume immune‐modulatory treatment after a serious infection has occurred depends on risk assessment for that patient, taking into account the infection being treated, the risk of recurrent infection, any interventions that can modify the risk and the need for psoriasis control. Live vaccines (e.g. MMR, varicella, zoster and yellow fever) are generally contraindicated in patients with psoriasis on immune‐modulatory agents, but this depends on the degree of immune suppression and individual risk factors. Wound healing in psoriasis is normal. Treatment with infliximab, adalimumab, etanercept, methotrexate and ciclosporin can safely be continued through low‐risk surgical procedures. For moderate‐ and high‐risk surgeries, a case‐by‐case approach should be taken based on the patient's individual risk factors and comorbidities. | |
dc.description.sponsorship | We are very grateful to AbbVie Pty Ltd (Australia) for an unrestricted educational grant | |
dc.format.mimetype | application/pdf | |
dc.language.iso | en_AU | |
dc.publisher | Blackwell Publishing Ltd | |
dc.rights | © 2018 The Australasian College of Dermatologists | |
dc.source | Australasian Journal of Dermatology | |
dc.subject | infection | |
dc.subject | psoriasis | |
dc.subject | surgery | |
dc.subject | therapy | |
dc.subject | vaccine | |
dc.subject | wound healing | |
dc.title | Psoriasis and infection. A clinical practice narrative | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.identifier.citationvolume | 60 | |
dc.date.issued | 2019 | |
local.identifier.absfor | 110304 - Dermatology | |
local.identifier.ariespublication | u3102795xPUB1535 | |
local.publisher.url | https://www.wiley.com/en-gb | |
local.type.status | Published Version | |
local.contributor.affiliation | Rademaker, Marius, Waikato Hospital | |
local.contributor.affiliation | Agnew, Karen, Greenlane Clinical Centre & Starship Children’s Hospital | |
local.contributor.affiliation | Anagnostou, Nicholas, Southern Adelaide Local Health Network | |
local.contributor.affiliation | Andrews, Megan, Specialist Connect | |
local.contributor.affiliation | Armour, Katherine, Skin and Cancer Foundation Inc | |
local.contributor.affiliation | Baker, Christopher M., The University of Melbourne | |
local.contributor.affiliation | Foley, P., The University of Melbourne | |
local.contributor.affiliation | Gebauer, Kurt, University of Western Australia | |
local.contributor.affiliation | Gupta, Monisha, University of New South Wales | |
local.contributor.affiliation | Marshman, Gillian, Flinders University Medical School | |
local.contributor.affiliation | Rubel, Diana, College of Health and Medicine, ANU | |
local.description.embargo | 2099-12-31 | |
local.bibliographicCitation.issue | 2 | |
local.bibliographicCitation.startpage | 91 | |
local.bibliographicCitation.lastpage | 98 | |
local.identifier.doi | 10.1111/ajd.12895 | |
local.identifier.absseo | 920117 - Skin and Related Disorders | |
dc.date.updated | 2021-02-21T18:55:41Z | |
local.identifier.scopusID | 2-s2.0-85052811984 | |
Collections | ANU Research Publications |
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