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Divergent features of the coenzyme Q:cytochrome c oxidoreductase complex in Toxoplasma gondii parasites

Hayward, Jenni; Rajendran, Esther; Zwahlen, Soraya; Faou, Pierre; van Dooren, Giel


The mitochondrion is critical for the survival of apicomplexan parasites. Several major anti-parasitic drugs, such as atovaquone and endochin-like quinolones, act through inhibition of the mitochondrial electron transport chain at the coenzyme Q:cytochrome c oxidoreductase complex (Complex III). Despite being an important drug target, the protein composition of Complex III of apicomplexan parasites has not been elucidated. Here, we undertake a mass spectrometry-based proteomic analysis of...[Show more]

CollectionsANU Research Publications
Date published: 2021-02-01
Type: Journal article
Source: PLOS Pathogens
DOI: 10.1371/journal.ppat.1009211
Access Rights: Open Access


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