Vascular changes in fetal growth restriction: clinical relevance and future therapeutics
Fetal growth restriction (FGR) affects about 5–10% pregnancies and is associated with poorer outcomes in the perinatal period. Additionally, long standing epidemiological data support its association with chronic diseases such as hypertension and diabetes. Cardiac and vascular adaptations in response to chronic hypoxemia due to utero-placental insufficiency are hallmarks of fetal adaptations. Investigators have attempted to identify these changes in the placenta at the microscopic and molecular...[Show more]
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|Source:||Journal of Perinatology|
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