Just How and Where Does P-glycoprotein Bind All Those Drugs?
P-glycoprotein (P-gp) was one of the first discovered, and most highly investigated, multidrug efflux pumps. P-gp was discovered in drug-resistant cancer cells and its ability to mediate adenosine triphosphate (ATP)-dependent efflux of drugs can confer resistance to cancer cells. The protein contains two sites for the binding and hydrolysis of ATP to power the active transport process. Drugs are known to bind within the transmembrane domain that comprises 12 membrane spanning α-helices....[Show more]
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