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Reactivity of monocyte-derived macrophages from patients with Crohn's disease

Vennonen, Ingrid; O'Brien, Claire; Pavli, Paul; Bhat, Purnima


Introduction: While usually seen as an autoimmune disease, the role of bacteria and pathogen-sensing by antigen presenting cells in the intestinal mucosa in Crohn's disease (CD) is becoming more apparent. The loss of integrity of the intestinal monolayer may allow bacterial penetration and trigger inflammation via interaction with tissue macrophages. Macrophages in the gut are solely derived from monocyte precursors in peripheral blood. They become resident (Type 2) macrophages upon entry...[Show more]

CollectionsANU Research Publications
Date published: 2016
Type: Conference paper
Source: Journal of Gastroenterology and Hepatology


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