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Increased small intestinal permeability in chronic liver disease is associated with reduced abundance of Faecalibacterium prausnitzii in the terminal ileum mucosa

Raj, A; Shanahan, Erin R.; Fletcher, L M; Tran, Cuong; Bhat, Purnima; Morrison, M; Holtmann, G; Macdonald, Graeme


Background and Aims: Chronic liver disease (CLD) is associated with dysbiosis of the stool microbiota, but little is known about the mucosal microbiota of the terminal ileum, some of which may be beneficial for mucosal integrity. Our aim was to evaluate for dysbiosis of the terminal ileum mucosal microbiota and identify associations with small intestinal permeability and disease severity in subjects with CLD. Methods: Subjects with and without CLD, undergoing routine colonoscopy...[Show more]

CollectionsANU Research Publications
Date published: 2016
Type: Conference paper
Source: Hepatology


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