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Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer

Ferreira, Manuel A; Gamazon, Eric R; Al-Ejeh, Fares; Aittomaki, Kristiina; Andrulis, Irene L; Anton-Culver, Hoda; Arason, Adalgeir; Arndt, Volker; Aronson, Kristan J; Arun, Banu K; Dahlstrom, Jane

Description

Genome-wide association studies (GWAS) have identified more than 170 breast cancer susceptibility loci. Here we hypothesize that some risk-associated variants might act in nonbreast tissues, specifically adipose tissue and immune cells from blood and spleen. Using expression quantitative trait loci (eQTL) reported in these tissues, we identify 26 previously unreported, likely target genes of overall breast cancer risk variants, and 17 for estrogen receptor (ER)-negative breast cancer, several...[Show more]

CollectionsANU Research Publications
Date published: 2019
Type: Journal article
URI: http://hdl.handle.net/1885/267187
Source: Nature Communications
DOI: 10.1038/s41467-018-08053-5
Access Rights: Open Access

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