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Stereocontrolled synthesis of (S)-Y-fluoroleucine

Padmakshan, Dharshana; Bennett, Simon; Easton, Christopher; Otting, Gottfried

Description

Starting with (S)-leucine, the corresponding γ-fluoride 8 has been prepared in a stereocontrolled fashion, by exploiting methods for the direct side-chain bromination of amino acid derivatives and silven(I) fluoride as the fluorinating reagent.

dc.contributor.authorPadmakshan, Dharshana
dc.contributor.authorBennett, Simon
dc.contributor.authorEaston, Christopher
dc.contributor.authorOtting, Gottfried
dc.date.accessioned2015-12-07T22:49:13Z
dc.identifier.issn0936-5214
dc.identifier.urihttp://hdl.handle.net/1885/26662
dc.description.abstractStarting with (S)-leucine, the corresponding γ-fluoride 8 has been prepared in a stereocontrolled fashion, by exploiting methods for the direct side-chain bromination of amino acid derivatives and silven(I) fluoride as the fluorinating reagent.
dc.publisherGeorg Thieme Verlag
dc.sourceSynlett
dc.subjectKeywords: amino acid derivative; gamma fluoroleucine; unclassified drug; article; bromination; drug synthesis; fluorination; halogenation; stereochemistry (S)-?-fluoroleucine; Amino acids; Halogenation; Silver fluoride; Stereoselective synthesis
dc.titleStereocontrolled synthesis of (S)-Y-fluoroleucine
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume2007
dc.date.issued2007
local.identifier.absfor030503 - Organic Chemical Synthesis
local.identifier.ariespublicationu4005981xPUB46
local.type.statusPublished Version
local.contributor.affiliationPadmakshan, Dharshana, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationBennett, Simon, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationOtting, Gottfried, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationEaston, Christopher, College of Physical and Mathematical Sciences, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.issue7
local.bibliographicCitation.startpage1083
local.bibliographicCitation.lastpage1084
local.identifier.doi10.1055/s-2007-977420
dc.date.updated2015-12-07T12:06:48Z
local.identifier.scopusID2-s2.0-34248202056
CollectionsANU Research Publications

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